Two UK centres are to be given £3.7 million to fund new treatments for people living with progressive MS, with the ambition that their disability can be slowed, stopped or ultimately reversed.
The MS Society centres in Cambridge and Edinburgh will be working together over the next five years to develop pioneering treatments for those who currently have nothing to stop their disability from deteriorating.
The two centres will be developing cutting-edge brain imaging techniques to test how effective drugs to repair myelin – the protective nerve coating which is damaged by MS – and protect nerves perform in clinical trials.
The MS Society Cambridge Centre for Myelin Repair aims to be the first MS centre in the world to routinely assess myelin in people with MS.
The Cambridge team will also build on their research on the impact of ageing on MS by studying myelin repair in people with MS of all ages, including children.
By looking at myelin repair across the human lifespan, the team hope to identify how the body’s natural ability to repair myelin changes with age, and work out how this could be used in the development of new myelin repair drugs.
“We are excited to build on the Cambridge centre’s strong foundations in developing new treatments for people with MS, and bring in what we believe will be a new era for MS treatment,” says Dr Thora Karadottir, who is leading the project alongside Professor Alasdair Coles.
“Thanks to this generous donation, we can make discoveries that will benefit people living with MS worldwide – including the myelin repair therapies that are still so desperately needed.”
Alongside this, the MS Society Centre for MS Research in Edinburgh will lead the development of a new drug-testing platform, which will use robots to screen thousands of possible treatments on zebrafish with an MS-like condition.
Potential treatments will also be tested on MS cells grown in a dish in the lab and on human brain tissue samples.
Using all these different methods together will help researchers prioritise treatments with the best chance of success in clinical trials.
“This pivotal investment from the MS Society will allow us to lead vital work in the study of nerve damage, which causes long-term disability in people living with MS,” says Professor Siddarthan Chandra, who is co-leading the work alongside Professors David Lyons, Anna Williams and Adam Waldman.
“We’ll be developing new ways to measure it, identifying new targets for treatments, and testing out the most promising in the lab.
“Our ultimate goal is that five years from now we’ll have substantially improved our understanding, and hopefully be beginning to translate this into new treatments that slow, stop or even reverse disability progression in MS.”
Emma Gray, assistant director of research at the MS Society, adds: “More than 130,000 people live with MS in the UK and our research has been vital in finding treatments for some of them.
“Today, we can see a future where nobody needs to worry about their MS getting worse – and our top priority is finding treatments that slow or stop MS for everyone.
“The work happening in Cambridge and Edinburgh is inventive, innovative and incredibly exciting, and will be vital to help us reach our goal.”
New company launched to drive forward Parkinson’s research
Charity Parkinson’s UK is to launch a new company dedicated to driving forward research into Parkinson’s disease.
Vivifi Biotech has been created to lead and plan preparations for a new trial into the role of the restorative protein glial cell-derived neurotrophic factor (GDNF) in Parkinson’s.
Launched through the charity’s drug development arm, Parkinson’s Virtual Biotech, up to £800,000 will be invested over the next two years as efforts continue to find a life-changing new treatment for people living with the disease.
Plans for a new trial build on the initial groundbreaking clinical investigations in GDNF, the results of which proved inconclusive but did show some signs that the treatment may have started to regenerate participants’ dopamine-producing brain cells.
“The unwavering passion and determination of the GDNF participant group has ensured that the potential of GDNF, and the role of patients in research, has never been forgotten,” says Paul Jackson Clark, director of engagement at Parkinson’s UK.
“They’ve tirelessly campaigned, fundraised and shared their experience with us, enabling us all to get to this monumental point.
“We now have the chance to see if we can find a life-changing new treatment that people with Parkinson’s desperately need. There are still plenty of obstacles but this announcement gives us the opportunity to move things forward together.”
Parkinson’s UK was the major funder of the initial trial, which investigated whether boosting levels of GDNF could slow, stop or reverse the progression of Parkinson’s.
Tom Phipps was a participant in the GDNF trial.
“My outcome was as positive as I could have wished for, I feel the trial brought me some time and has delayed the progress of my condition,” he says.
“The trial participants have always believed in GDNF’s potential,” said Parkinson’s UK in their announcement.
“So have we and the other organisations involved in the trial.
“Some participants tell us they’re still experiencing the benefits, years on from undergoing this experimental therapy. We’ve been working with them since the end of the trial.
“Together, we want to make sure we’ve explored every option.”
Music group launched to support BAME community
A music group established to support people living with dementia, memory loss and brain injury has received funding to launch an online project for the South Asian and BAME community.
Leicester Musical Memory Box (LMMBox) was founded in July 2018, and since that time has grown from one group in the city to six, providing interactive music sessions for people of all ages and backgrounds, including a group specific to the South Asian community.
The group – which has two staff members who are fluent in Gujarati, Hindi, Punjabi and Urdu – aims to provide the local community with a supportive network and a safe space to explore the unique challenges that a brain injury may bring to individuals, as well as their families and carers.
The new online music project is named ‘Geet Sangeet’ – translated as ‘Songs Sung Together’ – and will incorporate music and cultural references specific to the South Asian community, led by group leader Beena Masand from LMMBox.
Each session will begin with gentle exercises to warm up the body and brain, followed by singing and discussion about various music, songs, and media.
Attendees will also receive their own ‘musical memory box’ in a bag to help increase the interactivity of the sessions.
The project has received funding from the new Local Connections Fund, and is in collaboration with Headway Leicester.
Music has proven benefits for people with memory problems or a brain injury, including enabling people to connect with past experience and enabling freedom of expression, confidence and independence.
Attendance at the groups also helps to improve mood and reduce feelings of social isolation.
“We know we are providing a vital service to our members and receive enquiries regularly,” says Kyle Newman, group leader and co-director of LMMBox.
“In spite of the lockdown, we are thrilled to be able to once again provide a culturally specific group for the South Asian community.
“We also know that the group leader needs to come from that community and have the music and cultural knowledge to be able to engage participants effectively.”
“We are delighted to collaborate with LMMBox and reach out to more people across Leicester who have been affected by brain injury,” adds Mary Goulty, service manager at Headway Leicester.
“There is a clear need for a support service within the BAME community and that’s why we launched our BAME group last year, which is providing a vital lifeline to brain injury survivors we support and their families.”
To contact LMMBox, visit www.leicestermusicalmemorybox.co.uk
For support with brain injury in the Leicester community, visit www.headwayleicester.org.uk.
Art Therapy offers an emotional outlet for those living with a Traumatic Brain Injury (TBI)
Masks not only allow us to hide our true feelings but to also express them without fear of judgement.
Being able to ‘hide’ one’s true self, may be a way, for others, to truly ‘show’ themselves.
For this reason, Chroma therapists began delivering Art Therapy sessions online to those living with a Traumatic Brain Injury (TBI) in an attempt to help them express their emotions in a creative, non-threatening way.
A TBI can have devastating effects upon a person’s mental health, as well as physical, with emotional issues caused by significant, sudden changes in appearance and abilities.
Studies have found Art Therapy to be effective in helping TBI patients with emotional expression, socialisation, emotional adaptation to mental and physical disabilities, and communication in a creative and non-threatening way.1
Self-expression is fundamental in processing the effects of a TBI. Take a look at the image below.
On the left is the base mask. During the process of art therapy, across a number of sessions, the participant talks, reflects and begins to create ideas or metaphors which then get placed onto the base mask. Often this depicts the face he presents to the outside world, in contrast with the dual parts of to his inner personality including a bright peaceful side and a dark, tumultuous side.
Based on the sessions, Chroma therapists are better able to gauge the patient’s feelings, discuss the final piece and help the patient begin to process their emotions.
In effect, art therapy offers a creative gateway to communication and used in this way, tries to enable the participant to externalise their inner thoughts and feelings.
As a therapy, it has been shown to help reduce feelings of stress, promote creativity and imagination as well as increase self-expression, confidence and communication.
Chroma began delivering these sessions as a way to allow clients to reveal thoughts and feelings about themselves which they may find hard to express, or may not even be aware of, and which may be being expressed through more difficult behaviours.
They also create an opportunity for greater communication, allowing therapists to gain a deeper understanding of the client’s thoughts, anxieties and feelings.
Being able to express themselves creatively helps the client reveal their true feelings, which in itself can be cathartic – a relief to release their emotions, in a personal, safe space.
Chroma continues to deliver these sessions online to help reach as many TBI sufferers across the UK as possible in an attempt to help them begin to process their emotions concerning the effects the TBI had upon them, with the outlook to help improve their mental wellbeing which in turn will help promote a positive outlook to life and rehabilitation outcomes.
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