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Anxiety and PTSD linked to myelin in brain

If, as researchers suspect, extreme trauma causes increased myelin, the study could lead to new treatments



Anxiety and post traumatic stress disorder (PTSD) can be linked to increased myelin in the brain, a new study has revealed. 

The research linked anxiety behaviour in rats, as well as PTSD in military veterans, to increased myelin — a substance that expedites communication between neurons — in areas of the brain associated with emotions and memory.

The results, reported by scientists at the University of California, Berkeley, and UC San Francisco (UCSF), provide a possible explanation for why some people are resilient and others vulnerable to traumatic stress, as well as for the varied symptoms — such as avoidance behaviour, anxiety and fear — triggered by the memory of such stress.

If, as the researchers suspect, extreme trauma causes the increased myelination, the findings could lead to treatments — drugs or behavioural interventions — that prevent or reverse the myelin production and lessen the impact of extreme trauma.

“The combination of these studies in rats with our population of veterans with post traumatic stress disorders is, to me, really exciting,” said senior author Dr. Thomas Neylan, director of the Post Traumatic Stress Disorders Clinic and the Stress and Health Research Program at the San Francisco VA. 

“At least it’s another mechanism to think about as we develop new treatments. 

“If we see enduring ability to shape myelin content in an adult brain, maybe treatments will help reverse this. That’s where we want to go next with this.”

Researchers at the San Francisco Veterans Affairs Medical Center conducted brain MRI scans of 38 veterans — half with PTSD, half without — and found an increase in myelination in the grey matter of those with PTSD compared to that seen in the brains of those not suffering from PTSD.

The team at UC Berkeley discovered a similar increase in myelination in the grey matter of adult rats subjected to an acute stressful event. 

While not all rats showed long-term effects from the stress — just as not all traumatised veterans develop PTSD — those that did had increased myelination in specific areas of the brain associated with particular symptoms of stress that was identical to what UCSF physicians found in veterans with PTSD.

Both veterans with PTSD and stressed rats that exhibited avoidance behaviour had increased myelination in the hippocampus, often thought of as the seat of memory. 

Those exhibiting a fear response had increased myelination in the amygdala, which plays a key role in our response to strong emotions, such as fear or pleasure. 

Those suffering from anxiety had increased myelination in the dentate gyrus, a region critical to learning and memory.

“We understand that there’s a lot of individual variation in humans, but with rats, they’re genetically identical, so you think when you expose them to stress you’re going to get the same response,” said senior author Dr Daniela Kaufer, UC Berkeley professor of integrative biology. 

“But the response is extremely variable. They sort of fall into groups, such that some are really resilient, and some are vulnerable. 

“And the ones that are vulnerable are vulnerable in different ways: Some show avoidance behaviour, and some show fear learning problems, and some show startle responses that are exaggerated.”

According to Dr Neylan, similar individuality is seen in people with PTSD. The new study suggests that the specific symptoms are related to which areas of the brain are being newly myelinated.

“There’s a lot of heterogeneity across different people with PTSD; it’s not one size fits all. Every PTSD patient generally has a mix of different symptoms,” said Dr Neylan, professor-in-residence in psychiatry at the UC San Francisco Weill Institute for Neurosciences. 

“Some people are very avoidant. Some people are very hyper-reactive. The idea is that if you can show that these different symptom clusters have different neural circuitry, it might actually lead us closer to subtyping people in a way that we could be more targeted in our treatment.”

The new research builds on a project from 2014, when Dr Kaufer and her UC Berkeley colleagues discovered that rats subjected to acute stress produced more oligodendrocytes in the brain’s grey matter — specifically in the hippocampus. 

She proposed that this led to increased myelination of axons, potentially interfering with the speed at which signals traveled between different areas of the grey matter of the brain, such as the hippocampus and the amygdala.

Dr Neylan was intrigued by the 2014 findings and contacted Dr Kaufer, and they have been collaborating ever since. 


Girls and boys vary in negative experience of social media

The age at which each sex is most vulnerable to the negative impact differs, new data reveals



Girls and boys might be more vulnerable to the negative effects of social media use at different times during their adolescence, according to new research.

UK data shows that girls experience a negative link between social media use and life satisfaction when they are 11-13 years old and boys when they are 14-15 years old. 

This suggests sensitivity to social media use might be linked to developmental changes, possibly changes in the structure of the brain, or to puberty, which occurs later in boys than in girls. 

But, for both, social media use at the age of 19 years was again associated with a decrease in life satisfaction. 

At this age, say the researchers, it is possible social changes – such as leaving home or starting work – may make us vulnerable.

The team – including psychologists, neuroscientists and modellers from the Universities of Cambridge and Oxford, and the Donders Institute for Brain, Cognition and Behaviour – analysed two UK datasets comprising some 84,000 individuals between the ages of ten and 80 years old. 

These included longitudinal data – that is, data that tracks individuals over a period of time – on 17,400 young people aged 10-21 years old.

Social media has fundamentally changed how young people spend time, share information and talk to others. 

This has led to widespread concern about its potential negative impact. 

Yet, even after years of research, there is still considerable uncertainty about how social media relates to wellbeing. 

The team looked for a connection between estimated social media use and reported life satisfaction and found key periods of adolescence where social media use was associated with a subsequent decrease in life satisfaction.

The researchers also found teens who have lower than average life satisfaction later use more social media.

Dr Amy Orben, from the University of Cambridge, who led the study, said: “The link between social media use and mental wellbeing is clearly very complex. 

“Changes within our bodies, such as brain development and puberty, and in our social circumstances appear to make us vulnerable at particular times of our lives.

“I wouldn’t say that there is a specific age group we should all be worried about. 

“We should all be reflecting on our social media use and encouraging those conversations but we need to understand what is driving these changes across the age groups and between genders.

Professor Andrew Przybylski, of the Oxford Internet Institute, said: ‘To pinpoint which individuals might be influenced by social media, more research is needed that combines objective behavioural data with biological and cognitive measurements of development. 

“We therefore call on social media companies and other online platforms to do more to share their data with independent scientists, and, if they are unwilling, for governments to show they are serious about tackling online harms by introducing legislation to compel these companies to be more open.”

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Mental health impact of pandemic on older people revealed

Those who were shielding were almost twice as likely to experience depressive symptoms, research shows



Older people who were shielding throughout the COVID-19 pandemic were nearly twice as likely to experience depressive symptoms, new research has revealed. 

The study – the first to look at the mental wellbeing of older people in England – adds further evidence that isolation and shielding are strongly associated with depression, anxiety and lower quality of life. 

Lead author, Dr Giorgio Di Gessa, of UCL Institute of Epidemiology & Health Care, said: “When restrictions came into place in March 2020, around 3.8million (six per cent) people in the UK were ordered to shield, 74 per cent of whom were aged over 50. 

“Our study is the first of its kind to look at the effect shielding had on the mental wellbeing of older people in England. 

“We know from previous studies that the pandemic and policies restricting human interaction have posed a greater risk to mental health and well-being, especially among specific people in socioeconomic adversity, those with pre-existing poorer health, and those feeling lonely. 

“In our study we therefore took all these factors into account to understand if shielding and staying at home were additional factors contributing to poorer mental health among older people.”

The research team, from UCL and the University of Manchester, used data from over 5,000 adults aged over 50 who are part of the English Longitudinal Study of Ageing (ELSA) to investigate the link between shielding and mental health, after controlling for sociodemographic characteristics, pre-pandemic physical and mental health, and social isolation measures. 

The data was collected during the first eight to nine months of the pandemic, two of which were characterised by ongoing lockdowns.

Dr Di Gessa explained: “Our analysis supports the idea that shielding itself has been harmful, over and above other known vulnerabilities.

“One reason for this could be the psychological impact of being told so starkly of your own vulnerability and mortality and the policing of your own behaviour, and resulting anxiety and stress.”

Respondents were asked whether in April, June/July, and November/December 2020 they shielded (not going out of the house for any reasons), stayed at home (leaving only for very limited purposes, such as shopping for food, exercise, or essential work) or neither. 

Their mental health was then assessed by asking questions about depressive symptoms, anxiety, wellbeing and quality of life.

About 28 per cent of respondents reported that they shielded at least once, with five per cent shielding throughout the first eight to nine months of the pandemic. 

About a third reported staying at home all the time whereas 37 per cent neither shielded nor stayed at home. 

Among those adults who shielded at all times, in November and December 2020, 42 per cent reported elevated depressive symptoms compared to 23 per cent among those who never shielded nor stayed at home. 

Older people shielding throughout the period studied also reported the lowest life satisfaction and quality of life scores.

The researchers were able to account for pre-pandemic mental and physical health as well as for social contacts with family and friends and loneliness during the pandemic to better understand if the relationships observed between shielding and poorer mental health was driven by pre-existing conditions or reduced social interactions and higher loneliness during the pandemic.

“Policy makers need to be aware of adverse consequences for the mental health and well-being of those advised to shield or stay at home,” said Professor Debbie Price, co-author of the study, from the University of Manchester.

“If the long-term health and social wellbeing of older people is to be safeguarded, there must be careful thought given to addressing the mental health and wider needs of individuals at higher risk from COVID-19 variants, or future pandemics.”

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Arts and culture ‘can reduce anti-social behaviour’

The positive impact of taking part in such activities can last for up to two years, research reveals



Teenagers who take part in arts and cultural activities are less likely to engage in anti-social and criminal behaviour for up to two years later, new research has revealed. 

Researchers looked at data from more than 25,000 teenagers in the United States who had filled out questionnaires over several years.

They measured the teenagers’ overall engagement with arts activities based on a wide range of factors, from involvement in school clubs, orchestras, choirs, and arts classes outside school, to whether they had visited museums or been to concerts, or read on their own.

The team, from UCL and the University of Florida, found that the more of these activities the teenagers were involved in, the less likely they were to report being engaged in anti-social behaviour – ranging from misbehaving at school, to getting into fights, to criminalised behaviour such as stealing and selling drugs – both at the time of the first survey and when they were asked again about anti-social behaviour one and two years later.

The team also found that teenagers and young people who were more engaged in the arts were likely to have better self-control scores and view anti-social behaviour negatively. These outcomes have previously been found to make young people less likely to engage in anti-social and criminalised behaviours.

Senior author Dr Daisy Fancourt, of UCL Institute of Epidemiology & Health Care, said: “Past research has shown that getting involved in the arts can have a big impact on teenagers’ mental health and wellbeing.

Our study adds to evidence about the wide-ranging benefits that arts and culture can have for young people, demonstrating a positive link between the arts and a lower prevalence of anti-social behaviour.

“Notably these findings remained, even when taking into account factors such as children’s age, gender, ethnicity, socio-economic background, their parents’ educational background, where they lived, and their previous patterns of antisocial behaviours.”

Lead author Dr Jess Bone, also of UCL’s Institute of Epidemiology & Health Care, said: “Our definition of arts and cultural engagement was very broad. It included dancing and acting in school clubs, reading, going to cinemas, museums, concerts, and music classes, as well as other hobbies that teenagers took part in regularly.

“Finding ways to reduce antisocial behaviour among teenagers is important because these behaviours may become established and continue into adulthood, affecting someone’s whole life.

“Our findings demonstrate the importance of making arts and cultural activities available for all young people, particularly in the wake of the COVID-19 pandemic, which has limited access to and funding for these resources.”

Researchers looked at data from two US-based longitudinal studies, the National Longitudinal Study of Adolescent to Adult Health and the National Education Longitudinal Study of 1988, whose participants were nationally representative. 

The research team analysed questionnaires filled in by teenagers and their parents between 1988 and 2002. The average age of participants at the start of these studies was 14 to 15 years.

In one of the cohorts, about half of adolescents reported engaging in anti-social and criminalised behaviours in the last 12 months. The average number of times participants engaged in these behaviours over the year was 1.6.

Although the researchers found that arts engagement was linked to fewer positive perceptions of anti-social behaviour and better self-control scores, they could not conclude that these factors were causally responsible for the association between arts engagement and antisocial behaviour as the study was observational.

Nonetheless, in considering mechanisms through which the arts could reduce antisocial behaviour, the researchers cited previous studies showing improvements from arts engagement including increased empathy, more prosocial behaviour, reduced boredom and improved self-esteem, as well as better emotion regulation.

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