Connect with us
  • Elysium


Helping individuals with multiple disorders to help themselves

In dealing with psychiatric comorbidity, a varied and effective interdisciplinary team can have a strong impact on service users’ emotional and psychological wellbeing…



Psychiatric comorbidity refers to the presence of two or more mental disorders in one individual. It is an important concern for professionals as it is associated with a more severe course of illness, poorer prognosis and disproportionally higher levels of functional disability as compared to individuals with only one disorder.  

Research and clinical reflections highlight how psychiatric comorbidities for individuals with acquired brain injury (ABI; brain damage caused by events after birth):

  • Are relatively common.
  • Can remain clinically overlooked.
  • Can have a potentially negative impact upon rehabilitation outcomes.

Research indicates that individuals with ABI demonstrate elevated levels of psychiatric comorbidity and associated problems. These include psychiatric diagnoses, increased rates of self-harm and suicide attempts, alcohol and substance misuse problems.

Conversely, a US study demonstrated that those in psychiatric settings are more likely than the general population to have an ABI, more severe ABIs, and multiple ABIs.

These findings demonstrate the complex nature of the relationship between ABI and comorbid psychiatric diagnoses, requiring consideration.

Psychiatric comorbidities may be pre-existing, co-occurring or manifest post-onset. It may be beneficial to consider the varying temporal distinctions in turn and draw reflections upon clinical experience.


There is some evidence to suggest that pre-existing mental health difficulties and/or personality difficulties (as indicated by three factors; ICD-9 diagnoses, psychiatric medication prescription and psychiatric service utilisation) may increase the likelihood of acquiring a traumatic brain injury.

Additional clinical reflections appear to suggest that consideration of pre-existing psychological difficulties may provide some insight into the predisposing and precipitating factors involved with the ABI’s onset.  Such examples include:

  • Service users suffering from depression and/or mood instability, may engage in self-harm and/or suicide attempts through ligating and/or overdose. If unsuccessful, such attempts can result in anoxia or hypoxia leading to diffuse neurological damage.
  • Patterns of risk behaviour associated with personality difficulties and/or mood instability such as impulsive and/or reckless acts can result in an ABI through accidental injury (e.g. RTA following dangerous or drink driving).
  • Factors associated with psychosis may lead individuals to become vulnerable and targeted within the community leading to potential victimisation and physical assaults potentially leading to a TBI.
  • A history of substance or alcohol misuse (which has been robustly demonstrated to be highly correlated with mental health and personality difficulties) after acute or chronic abuse, can lead clients to develop alcohol related brain damage (ARBD) such as Korsakoffs syndrome.

All such case examples have been observed within my time in neuropsychiatric services.

Moreover, whilst the onset of a neurological condition may result in a personality change, more often a “disinhibition and an exaggeration of pre-injury personality traits” is observed.

Therefore, consideration of pre-existing difficulties could shed light into the potential reaction to, and engagement with, rehabilitation efforts.


These are potentially organic changes occurring directly as a result of the injury or illness. These need to be taken into consideration during the recovery stages following the onset of a neurological condition.

During the acute recovery stage, behavioural disturbances including agitation, aggression and confusion are often observed. Moreover, a broad range of emotional and behavioural abnormalities may indicate psychological and psychosocial deficits.

In my experience these are often the most problematic for the individual and for those involved in their care.

The most severe psychiatric disorders are characterised by the presence of one or more of the following symptoms: delusions; hallucinations; serious disorder of thought form; severe disturbance of mood; and sustained or repeated irrational behaviour.


These include post-injury psychological reactions to disability and trauma.

These may be evident immediately in the short-term period directly following onset of the ABI and appear functionally related (e.g. PTSD symptoms following a discrete event), or they may manifest distally in the longer term as a result of subsequent event chains evolving from the injury (e.g. long-term poor self-esteem and depression resulting from loss of job and associated status).

There is considerable psychological and neurobehavioural evidence available which supports the hypothesis that ABI increases an individual’s risk of developing subsequent psychiatric disorders in the long term.

These studies tend to focus upon major psychiatric disorders. Research indicates increased rates of disorders such as major depression, bipolar affective disorder, and generalised anxiety disorder in addition to schizophrenia.

Evidence has also been found to indicate high rates of borderline and avoidant personality disorders in those with ABI.

In my clinical practice this may, in part, explain the high rates of anxiety, low mood, low self-esteem, low motivation and low levels of psychological wellbeing often observed within inpatient ABI settings, and are found to be common in survivors of ABI.

Impact upon rehabilitation

Consideration of the potential impact of the constellation of psychological factors involved with an ABI is central to rehabilitation efforts. However, refection upon ABI services identifies factors which may impede such attempts.

Diagnostic overshadowing is the attribution of an individual’s symptoms to one overarching condition, when such symptoms actually suggest a comorbid condition. This issue is increasingly recognised within the intellectual disability field, and may also be prevalent within ABI.

Relating specifically to TBI, “once a diagnosis is made of a major condition…there is a tendency to attribute all other problems to that diagnosis, thereby leaving other co-existing conditions undiagnosed” (Neurotrauma Law Nexus, 2020).

The presence of specialist neurological professionals trained and experienced in identifying and treating a range of organic disorders may increase the likelihood that presenting symptoms are attributed to a neurological cause.

Professionals may view the client with a ‘neurological lens’, filtering out markers which may indicate psychological and/or emotional difficulties. As such, the main focus of rehabilitation efforts tends to be upon physical and cognitive rehabilitation, with consideration of clients’ psychological and emotional wellbeing remaining unaddressed.

Additionally, the hierarchical structure of the medical model dictates that the clinical areas addressed first are those which are considered to be most ‘severe’, and are often those considered more ‘organic’.

ABI services tend to address the physical, cognitive, psychiatric, and psychological/emotional difficulties, in that order.

This prioritisation process, coupled with least restrictive practice efforts, mean that clients can be reintegrated into the community with outstanding mental health difficulties and psychological/emotional difficulties. With limited and stretched community resources, these needs can ultimately remain unmet.


I believe that clinicians’ experiences shape and colour the lens through which they view their clients. This can at times be a challenge for those coming into a neuropsychiatric field from a mental health background.

With clinicians tending to ‘read’ certain presentations with a behavioural or psychological interpretation rather than an organic one.

For example, considering the potential presence of psychosis for a service user presenting with confusion, bizarre behaviour, and reporting visual hallucinations, rather than immediately referring the individual for a UTI screen or CT scan.

More attention and research into the common psychiatric comorbidities within neuropsychiatric services is needed. Consideration of these comorbidities may serve to guide suitable pathways, inform rehabilitation goals and efforts with the aim of increasing emotional and psychological wellbeing.

This article serves to highlight the need to identify and consider psychiatric comorbidities in the comprehensive and holistic assessment of an individual to increase rehabilitation efficacy.

Dr Sarah Ashworth is a forensic psychologist at Cygnet Grange, a neuropsychiatric rehabilitation facility in Mansfield. For more information please call 01623 669 036 or visit

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *


Taking time to look back – so the way ahead is clearer



Reflective practice within healthcare settings is widely talked about, but not always so easy to implement in the workplace. NR Times speaks to one neurological centre about how it benefits patients and staff there.

Reflective practice and discussion in healthcare settings is a professional requirement for nurses, as laid out by the Royal College of Nursing revalidation requirements as part of their continuous professional development.

It allows professionals to take time to pause and reflect, communicate and plan, which undoubtedly leads to better outcomes for patients and staff.

But in reality, reflective practice can often be left to the bottom of the pile, underneath many of the competing responsibilities facing staff who are often pressed for time.

It could be argued that this is also why reflective practice is so important – healthcare staff are facing so many pressures that it actually makes less sense to neglect the important work of individual and team reflection.

The Royal College of Nursing defines reflective practice as: A conscious effort to think about an activity or incident that allows us to consider what was positive or challenging and if appropriate
plan how it might be enhanced, improved or done differently in the future.

Staff at Elysium St Neots Neurological Centre in Cambridgeshire started doing regular, weekly reflective practices when its new hospital director, Fiona Box, came into the role a few months ago.

The nurses and healthcare assistants from a ward are invited into the meetings and in their absence the therapy staff monitor patients and provide activities.

“We thought it would be helpful for team members to give them the opportunity to think, learn, and to hear their opinions,” says charge nurse Jemima Vincent.

“If we have an incident with a patient, we discuss it in the session” she says.

Sessions are led by the management team, with added input from psychology teams on each ward.

They will talk through any strengths, weaknesses and opportunities, and work through an analysis to learn from the incident and create an action plan.

They talk about the worst-case scenario in relation to an individual situation and discuss how staff would manage that, so they’re better prepared in the event of it happening.

While they focus on one patient at a time, issues arise during conversations that bring in their wider experiences.

In an article* published in the Nursing Times in 2019, Andrea Sutcliffe, chief executive of the Nursing and Midwifery Council said: “In these challenging times for health and social care, it’s so important that collectively we do all we can to support our health and care professionals, and their employers, in devoting time to individual, reflective, personal and honest thinking.”

Fiona has received encouraging feedback from staff, who say the meetings help the staff feel much more involved in a patient’s care and allow the team to increase their knowledge and understanding resulting in a more consistent way of working.

“Healthcare workers often don’t fully understand patients’ diagnoses or why they’re reacting in a certain way, for example,” Jemima says.

“They know a patient presents with certain behaviours and may be taking medicine to help them cope but they’re not aware why the patient is showing signs of aggression and the best response to deescalate the situation,” she says.

“It’s a learning opportunity for staff, because reflective practice means that they can understand a patient’s diagnosis and why they behave how they do,” Jemima says.

“Reflective practice answers their ‘why’ questions, and gives them a more open mind.”

Jemima also benefits from the meetings; it’s a way for her to get to know staff better, especially when it comes to learning opportunities.

“I’m able to understand what level of support each member of the team requires, including training needs and if they need more knowledge on a specific topic.”

In her final year as a mental health nurse student on extended clinical placement at Elysium St. Neots, Jo took part in a reflective practice session.

She had just finished her dissertation, in which she looked at how settings can increase the opportunities and variety of reflective practices within hospital settings.

The aim of Jo’s session was to reflect on the recent deterioration in a patient’s mental state and the resulting impact on their well-being to ensure staff had a consistent approach to support the patient.

The hospital’s director Fiona asked the team about the patient’s care plan, diagnoses and needs and wishes.

Where staff were unsure of the answers to questions, Jo says Fiona gave them answers and encouraged the team to share their knowledge of the patient, problem solve and come up with an agreed plan to move forward with.

Jo found the session helpful and was impressed with how the healthcare assistants were so involved in the discussions about all aspects of the patient’s care, including the more clinical elements.

Healthcare assistants told her they found the session helpful too and that it made them feel like they had a better understanding of the patient’s changing mental state, behaviours and needs.

Jo says having the opportunity to reflect on practice is a crucial skill for all healthcare workers to help them learn from their experiences and increase self-awareness, which, in turn, can improve individual professional standards, strengthen teams and enhance patient-centred care and clinical outcomes.

For referrals to Elysium St Neots Neurological Centre or other Elysium centres visit:

Reference source: professional-regulation/nmc-highlights-importance-of-nurses- reflection-on-practice-18-06-2019/

Continue Reading


Robots and resilience at Askham Rehab



NR Times reports on a new rehabilitation approach taking place in Cambridgeshire.

Despite a year of relentless change and upheaval for all involved in neuro-rehab, one provider in Cambridgeshire has been able to keep its ongoing development on track.

Askham Rehab, part of the Askham Village Community, is a recently-launched specialist rehabilitation service incorporating the latest in rehab robotics and sensor assisted technology.

While the firm has invested in state-of-the-art technology to do the heavy lifting, however, its rehab services remain person-centred, as director Aliyyah-Begum Nasser explains.

“We’re a specialist rehab centre in essence, and so, although the robotic technology helps us to get the most out of our patients and staff, we are very much family-focused.

The equipment is obviously fantastic but we know from experience that a person’s mindset, and their ability to sustain whatever improvements they make, comes down to the people who are supporting them – their family members.

“We’ve been on some real journeys with many of our family members who just didn’t understand the impact of a brain injury in terms of how it can impact behaviour or what it can do for cognition.

“Once they understand that, suddenly they become a lot more compassionate, and a lot more supportive; they become part of the recovery process, rather than being a frustrated observer.”

With recognition of the family’s paramount importance to recovery, Askham Rehab does everything within its power to harness this force – including by enabling families to stay together in specially-designed apartments on site.

Aliyyah-Begum says: “The flats are fully adapted, with cantilever cupboards, height-adjustable sinks in the bathroom and full wet room with turning spaces.

“We have the patients themselves participating in rehab, specifically to their programme, but relatives are also there from the beginning, seeing the improvement and being part of our process from the outset.

“We think of the centre as more of a rehab environment; it’s not a just care home with therapy as an added extra.

“So from the minute our patients wake up to the minute they go to bed, everything is based around their recovery goals, and everyone is working together towards achieving them.”

And robotics are an important tool in pursuing these goals through patient exercise. They help therapists to achieve the repetitions and intensity needed to progress their clients, as Aliyyah-Begum explains.

“The point of the robotics is that they respond to the patient. For example, if you set the machine on a left lower limb, but it senses that there is more pressure being exerted through the right limb than the left, it will automatically respond to make sure the patient is moving the correct part of their body.”

The centre’s head of rehab and nursing, Priscilla Masvipurwa, says: “This is a real a game changer in our approach to rehabilitation.

“Robotics help to bridge the gap, increasing the frequency and repetitiveness of treatment, something that’s an essential part of the process.

“We anticipate that this will enable us to support our patients in reaching their goals in a more efficient and sustainable way.

“The centre has so far invested in four items from robotic rehabilitation firm Tyromotion, but is looking to add more over time, as the benefit to both staff and patients becomes ever more evident.

Aliyyah-Begum says: “It’s really important to the team at the centre that the robotics aren’t just seen as an add on.

“There is a lot of nervousness about robots replacing therapists, but our service is still very much therapy-led.

“What this means in practice is that, where a resident would previously have had maybe an hour of therapy time in an afternoon, now you have an hour of therapy time, and then you can carry on exercising if you want to, or carry on playing games with other residents.

“For example, one of our machines, the Myro, enables patients to play games like bat and ball, or perform virtual tasks like sweeping leaves.

“However, because it is all sensor-assisted, if it senses that the patient needs to work a certain hand, it will alter what it is asking them to do accordingly, while they won’t even necessarily feel they’re having therapy – it’s all part of the game, and part of their socialising with other residents.”

Askham Rehab forms part of the Askham Village Community, on the edge of Doddington village, in Cambridgeshire.

It provides specialist care for people of all ages, offering day visits, respite care and continuing long-term support, both on-site or at home.

The site consists of five homes, three of which are specialist neurological facilities. In total, the neuro-rehab team can look after up to 52 patients at any one time, with 120 staff made up of rehab professionals and specialists.

The team comprises carers nurses, physiotherapists, occupational therapists, speech and language therapists and psychologists.

Aliyyah- Begum believes that the introduction of the robotic rehab services, combined with the patient-led therapy the group has been offering for 30 years, can only enhance the centre’s outcomes.

She adds: “We know that there is an increasing number of care homes that offer specialist therapy, but the difference with Askham Rehab is that we have embedded it into the whole culture of our setting – and the outcomes really speak for themselves.

“We often discharge people earlier than planned, and that’s a testament to the fact that the patients are really working hard with the team throughout their stay with us to achieve their goals – and that is the key.”

For more information about Askham Rehab, visit

Continue Reading


Astrocytes identified as master ‘conductors’ of the brain



In the orchestra of the brain, the firing of each neuron is controlled by two notes – excitatory and inhibitory – that come from two distinct forms of a cellular structure called synapses.

Synapses are essentially the connections between neurons, transmitting information from one cell to the other. The synaptic harmonies come together to create the most exquisite music–at least most of the time.

When the music becomes discordant and a person is diagnosed with a brain disease, scientists typically look to the synapses between neurons to determine what went wrong. But a new study from Duke University neuroscientists suggests that it would be more useful to look at the white-gloved conductor of the orchestra – the astrocyte.

Astrocytes are star-shaped cells that form the glue-like framework of the brain. They are one kind of cell called glia, which is Greek for “glue.” Previously found to be involved in controlling excitatory synapses, a team of Duke scientists also found that astrocytes are involved in regulating inhibitory synapses by binding to neurons through an adhesion molecule called NrCAM. The astrocytes reach out thin, fine tentacles to the inhibitory synapse, and when they touch, the adhesion is formed by NrCAM. Their findings were published in Nature on November 11.

“We really discovered that the astrocytes are the conductors that orchestrate the notes that make up the music of the brain,” said Scott Soderling, PhD, chair of the Department of Cell Biology in the School of Medicine and senior author on the paper.

Excitatory synapses — the brain’s accelerator — and inhibitory synapses — the brain’s brakes — were previously thought to be the most important instruments in the brain. Too much excitation can lead to epilepsy, too much inhibition can lead to schizophrenia, and an imbalance either way can lead to autism.

However, this study shows that astrocytes are running the show in overall brain function, and could be important targets for brain therapies, said co-senior author Cagla Eroglu, PhD, associate professor of cell biology and neurobiology in the School of Medicine. Eroglu is a world expert in astrocytes and her lab discovered how astrocytes send their tentacles and connect to synapses in 2017.

“A lot of the time, studies that investigate molecular aspects of brain development and disease study gene function or molecular function in neurons, or they only consider neurons to be the primary cells that are affected,” said Eroglu. “However, here we were able to show that by simply changing the interaction between astrocytes and neurons — specifically by manipulating the astrocytes — we were able to dramatically alter the wiring of the neurons as well.”

Soderling and Eroglu collaborate often scientifically, and they hashed out the plan for the project over coffee and pastries. The plan was to apply a proteomic method developed in Soderling’s lab that was further developed by his postdoctoral associate Tetsuya Takano, who is the paper’s lead author.

Takano designed a new method that allowed scientists to use a virus to insert an enzyme into the brain of a mouse that labeled the proteins connecting astrocytes and neurons. Once tagged with this label, the scientists could pluck the tagged proteins from the brain tissue and use Duke’s mass spectrometry facility to identify the adhesion molecule NrCAM.

Then, Takano teamed up with Katie Baldwin, a postdoctoral associate in Eroglu’s lab, to run assays to determine how the adhesion molecule NrCAM plays a role in the connection between astrocyte and inhibitory synapses. Together the labs discovered NrCAM was a missing link that controlled how astrocytes influence inhibitory synapses, demonstrating they influence all of the ‘notes’ of the brain.

“We were very lucky that we had really cooperative team members,” said Eroglu. “They worked very hard and they were open to crazy ideas. I would call this a crazy idea.”

Continue Reading


Get the NR Times update