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Irregular brain responses ‘help understanding of mental illness’



Irregular responses in the brain to challenging tasks and mistakes could be key to understanding common links between abnormal behaviours in a range of mental illness and cognitive disorders, a new study has found. 

Researchers reviewed studies that measured brief electrical tremors – naturally occurring electrical vibrations produced in areas at the front of the brain – using EEG, an electrophysiological monitoring method to record electrical activity on the scalp. 

By collating the findings from the studies, the team from King’s College London found that brain waves, known as ‘theta activity’, in people with conditions like anxiety, OCD and ADHD are different following mistakes or challenging situations compared to the theta activity in those without any disorders.

The results show that such conditions are strongly linked to brainwaves that oscillate in consistently divergent ways from the brains of those without any illness in the midfrontal region of the brain. 

The researchers suggest that with further investigation measurements of theta activity have the potential to improve diagnostic methods and the effectiveness of currently available treatments like Cognitive Behavioural Therapy (CBT).

Oscillations in the theta frequency range are becoming increasingly recognised as related to behavioural and cognitive control, hallmarks of healthy behaviour, and disruption in these oscillations have been connected to a range of psychiatric illnesses. 

This study establishes that, in more than one type of mental illness, theta-related signals act in ways that diverge from the behaviours seen in the brains of those without any disorders.

In anxious individuals, for example, research suggests that there is a significantly higher degree of frontal-midline theta activity compared to non-anxious individuals, and that could be associated with more reactive control modes of behaviour in the moment rather than proactive behaviours such as planning and preparation.

The review also found recent studies of ADHD suggest that a dysregulation of theta signals when performing tasks resulted in a different type of negative effect on performance. 

Again, in tests that measure response times, the theta activity in individuals with ADHD rises either too early or too late for them to make an appropriate decision based on what they perceive. Similar levels of dysregulation are found in those with substance use disorder.

“From our review, we see that a healthy brain is one in which we see consistent levels of theta activity at the right moments,” says Dr Grainne McLoughlin, senior lecturer in the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London. 

“Theta activity in an anxious person for example is imbalanced over time compared to someone without anxiety. 

“Someone experiencing anxiety, while able to take in new information, isn’t able to alter their cognitive behaviour effectively going forward because they are over focused on reacting immediately to environmental stimuli. 

“Consistency and balance in these signals are thought to be essential for effective communication between brain regions, and appropriate and timely responses to our environment.”

Dr Scott Makeig, the study’s lead investigator from the University of California San Diego and who has long investigated ways to map and model frontal theta activity, said: “Frontal midline theta complexes in scalp-recorded brain electrical signals play essential roles in these transient theta network events which also seem to synchronise higher-frequency activities to regulate communication between brain executive, sensory and motor areas supporting quick behavioural responses and situational awareness of their consequences. 

“This review suggests a role of abnormalities in these theta network events in producing a range of symptoms associated with mental illness.”

The investigators propose that this research has the potential to improve diagnostics and help shape future treatments.

Dr McLoughlin said: “Analysis of these brainwaves shows that certain brains may be programmed to respond sub-optimally to the environment. 

“Improving the consistency and balance of these signals in the brain may be an important first step as there is the potential to improve the effectiveness of treatments like CBT. 

“Our research shows that without consistency and balance in theta oscillations, it can be difficult to process new information and voluntarily guide behaviour. 

“This research in time could help clinicians to have a greater consideration for how the brain responds to situations so that therapies like CBT can be applied more effectively.”


Discrimination ‘can cause mental health and behaviour issues’

The UCLA study reveals both the short- and long-term psychological and behavioural impact on young adults



Young adults who have experienced discrimination have a higher risk of both short- and long-term psychological and behavioural problems, a new study has found. 

Researchers at UCLA examined a decade’s worth of health data on 1,834 Americans who were between 18 and 28 years old when the study began. 

They found that the effects of discrimination may be cumulative — that the greater number of incidents of discrimination someone experiences, the more their risk for mental and behavioural problems increases.

The study also suggests that the effects of discrimination in young adults are connected with disparities in care for mental health concerns and institutional discrimination in health care overall, including inequities in diagnoses, treatment and health outcomes.

Previous studies have linked discrimination — whether due to disability, racism, sexism, ageism, physical appearance or other biases — to a higher risk for mental illness, psychological distress and drug use. 

While previous research has examined the correlation in childhood or later adulthood, this new study is the first to focus on the transition to adulthood and to follow the same group of individuals over time.

“With 75 per cent of all lifetime mental health disorders presenting by age 24, the transition to adulthood is a crucial time to prevent mental and behavioural health problems,” said Yvonne Lei, a medical student at the David Geffen School of Medicine at UCLA and the study’s corresponding author.

Lei also said the findings are particularly relevant in light of the stresses young adults are facing globally today.

“The COVID-19 pandemic has brought to the forefront new mental health challenges — particularly for vulnerable populations,” she said. 

“We have the opportunity to rethink and improve mental health services to acknowledge the impact of discrimination, so we can better address it to provide more equitable care delivery.”

Researchers used data spanning 2007 to 2017 from the University of Michigan’s Transition to Adulthood Supplement of the Panel Study of Income Dynamics survey. 

Approximately 93 per cent of the people in the study reported experiencing discrimination; the most common factors they cited were age (26 per cent), physical appearance (19 per cent), sex (14 per cent) and race (13 per cent).

The analysis showed that participants who experienced frequent discrimination, defined as a few times per month or more, were roughly 25 per cent more likely to be diagnosed with a mental illness and twice as likely to develop severe psychological distress than those who had not experienced discrimination or had experienced it a few times per year or less. 

Overall, people who experienced any amount of discrimination had a 26 per cent greater risk for poor health than people who said they did not experience discrimination.

During the ten-year period, young adults in the study who had experienced multiple successive years of high-frequency discrimination showed a much more pronounced, cumulative risk for mental illness, psychological distress, drug use and worse overall health.

The findings shed light on the multidimensional impact of discrimination on mental and behavioural health and overall well-being.

“The associations we found are likely also intertwined with mental health care service disparities — including inequities in care access, provider biases and structural and institutional discrimination in health care — leading to inequities in diagnoses, treatment and outcomes,” said the study’s senior author, Dr Adam Schickedanz, an assistant professor of paediatrics at the Geffen School of Medicine.

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Sleep problems and fatigue ‘directly linked to COVID-19’

Mental illness as a direct result of COVID infection is less certain, say researchers



The link between COVID-19 with sleep problems and fatigue has been confirmed by a new study into the impact of the virus – although doubt exists over whether infection is directly responsible for mental illness. 

People who tested positive for COVID were found to have an increased risk of such issues, with a six-fold increase in the likelihood of reporting fatigue to a GP, and a three-fold increase in the risk of sleep problems. 

There was also an 83 per cent increase in mental illness following a positive PCR test, although this was also recorded as being 71 per cent among those without COVID. 

The researchers on the study, led by the University of Manchester, say this does cast doubt as to whether COVID directly causes mental illness, as this finding also includes other mental health risk factors like pandemic-related anxieties, and whether people with mental illness may be more likely to seek a test. 

The findings were compiled through analysis of electronic primary care health records of 226,521 people from across the UK. 

Dr Matthias Pierce, who led the work at The University of Manchester, said: “When we began this research project we wanted to investigate whether we could find any evidence in primary health care records that COVID-19 was linked to an increased risk of mental health illness, sleep and fatigue problems.

“While fatigue is clearly a consequence of COVID-19 the risk of experiencing sleep problems is also very high. However, we are sceptical regarding the extent that COVID-19 is directly causing people to become mentally ill, or whether those with a predisposition to mental illness are more likely to get tested.”

“This study shows a clear association between COVID-19 infection and fatigue and sleep problems,” says Professor Trudie Chalder, a cognitive behavioural psychotherapy specialist at King’s College London’s Institute of Psychiatry, Psychology and Neuroscience (IoPPN).

The next research steps will be to explore mechanisms of such associations and targeted interventions.”

Professor Roger Webb, who co-leads the Mental Health research programme at the National Institute for Health Research Greater Manchester Patient Safety Translational Research Centre (NIHR GM PSTRC), which funded the study, added: “Our findings align with those generated by investigations conducted in other countries in revealing elevated risks of mental illness, self-harm, fatigue, and disrupted sleep patterns among people testing positive for infection during the pandemic. 

“Establishing the mechanisms that have caused these outcomes to occur is the next major challenge for researchers in our field.”

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Parental depression ‘can impact child’s mental health and academic progress’

Both maternal and paternal depression can impact on a child’s mental wellbeing and education, a study has revealed



Children who live with a parent who has depression are more likely to develop depression themselves and to not achieve educational milestones, a new study has found. 

Maternal depression is a known risk factor for depression in children and is associated with a range of adverse child health and educational outcomes including poorer academic attainment. 

To date, however, risk factors associated with paternal depression have been less well examined.

Understanding the effects of timing of both maternal and paternal depression of offspring outcomes has implications for prevention and early intervention.

The authors, from Swansea University, said: “Children who live with a parent (mum or dad) who has depression are more likely to also develop depression and not achieve as well in school, compared to children who live with a parent with treated depression. 

“Working with families and treating parental depression (in dads as well as mums) is likely to have long-term benefits for children’s mental health and educational attainment. This has never been more important than after lockdown and COVID, as depression is contagious too.”

In the new study, a team – led by Sinead Brophy from Swansea University Medical School – used data from the Secure Anonymised Information Linkage (SAIL) databank assembled as part of the Born in Wales Study funded by the Welsh Government. 

Information on children born in Wales from 1987 to 2018, as well as their mothers and fathers—or stable, adult male figure in the same household—was used in the study. Both parental and child diagnosis of depression was attained from general practitioner records in the SAIL databank.

Overall, 34.5 per cent of mothers and 18 per cent of fathers/stable men had a diagnosis of depression. 

In offspring, 4.34 per cent of all children – 2.85 per cent of boys, and 5.89 per cent of girls – were diagnosed with depression. 

Children were more likely to develop depression if their mother had depression before or after their birth, a risk which increased when their father/stable man also had depression. 

In addition, the odds of achieving milestones at the end of primary school were significantly decreased if either parent had depression.

Other risk factors for children’s depression identified in the study included being female, their mother taking antidepressants and having no stable man in the household. 

The authors conclude that the impact of paternal depression requires more attention than has previously been given, and suggest that holistic approaches to whole family wellbeing and depression will help ensure positive outcomes for children.

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