A new wearable device which can help stroke survivors regain arm function through delivering tiny electrical pulses is to be developed by researchers in the UK in a groundbreaking project.
The new Sheffield Adaptative Patterned Electrical Stimulation (SHAPES) device, the function of which is likened to a highly advanced TENS machine, is to be built and tested following a £1.2m grant award from the National Institute for Health Research’s ‘Invention for Innovation’ programme.
Through a unique combination of electronic design and programming, the SHAPES technology is able to deliver continuous moving patterns of tiny electrical pulses to the arm to multiple areas at any given time.
The intensity, timings and combinations of pulse delivery can also be programmed to be automatically adjusted. Previous research suggests that this variability in sensations is important in improving recovery from the muscle stiffness caused by stroke.
The SHAPES technology will be tested on patients, recruited between two to 16 weeks post-stroke, in a clinical trial later this year. It is hoped that the technology will improve rehabilitative outcomes for stroke patients at an optimal point in their recovery and will be cost-effective for the NHS to use.
The project is scheduled to last 39 months, with trial results expected in spring 2024.
The new device builds on the expertise in electrical stimulation research of the clinical engineering team at Sheffield Teaching Hospitals NHS Foundation Trust.
The Trust is to work in partnership with the NIHR Devices for Dignity MedTech Co-operative, University of Sheffield’s School of Health and Related Research, Coventry University, Barnsley Hospital NHS Foundation Trust, and Medipex Limited during the three-year study.
Dr Siva Nair, consultant neurologist at Sheffield Teaching Hospitals NHS Foundation Trust and lead for the clinical trial, says: “Our device is a significant technological advancement in the field of therapeutic electrical stimulators.
“Muscle stiffness in the arm is a major barrier to rehabilitation after stroke, so we are really pleased that we have received funding to test this innovative form of treatment. If our study is successful it will lead to a novel therapy for the rehabilitation of muscle stiffness after stroke.
“The technology also has the potential to be useful in the treatment of muscle stiffness in several other diseases of the brain and spinal cord, such as head injury and multiple sclerosis which could offer renewed hope to thousands of patients living with the consequences of debilitating neurological conditions.”
Professor Adewale O Adebajo, 63, had a life-threatening bleed on his brain in 2015 while working at Barnsley Hospital. He said the new technology is important in addressing an unmet need in stroke survivors.
“Excessive muscle stiffness in an arm is a really unpleasant and painful consequence of having a stroke. I was mainly wheelchair dependent following my stroke and I suffered a lot of weakness in my left side, but one of the things I wanted to do during my recovery was to use my left arm,” he says.
“I love playing table tennis, but I couldn’t do that, and when I would lift my arm up and let it go it was just like dead wood. It was very unpleasant.
“In my opinion Sheffield is a world leader in stroke research, so this new technology, if successful, could really help in reducing pain and symptoms and in restoring arm function.”
Women ‘under-represented in stroke trials for 30 years’
‘Put policy into practice so future research can address gaps in the understanding and treatment of stroke in women’
Women have been under-represented in stroke clinical trials for the past 30 years, new research has found, making it harder to interpret what the findings really mean for them.
The study found that more than three quarters of the trials enrolled less women than the expected proportion that experience stroke in the community.
George Institute researchers looked at 281 stroke trials that had at least 100 participants and were conducted between 1990 and 2020.
The total number of participants was 588,887, of whom 37.4 per cent were women, but the average prevalence of stroke in women across the countries included was 48 per cent.
“It’s now time to put policy into practice so that future research can address our knowledge gaps in the understanding and treatment of stroke in women,” said study co-author Dr Katie Harris.
While there have been studies showing varying degrees of representation of women in cardiovascular trials, this issue has only recently started to be examined in relation to stroke trials.
The greatest differences were seen in trials involving a particular type of stroke known as intracerebral haemorrhage, those where the mean age of participants was less than 70.
Lead author Dr Cheryl Carcel, from The George Institute for Global Health and a Heart Foundation Fellow, said that while both women and men had the same one-in-four risk of experiencing a stroke in their lifetime, women were much older and in worse health at the time they have a stroke.
“These findings have implications for how women with stroke may be treated in the future, as women typically have worse functional outcomes after stroke and require more supportive care,” said Dr Carcel.
Dr Carcel said the reasons for this under-representation were complex and most likely due to a number of factors, including recruitment criteria that unintentionally exclude women like age and having other health conditions.
“Patient attitudes and beliefs can also be a factor, and there can even be a potential bias among the clinical staff conducting the study,” she said.
“Our previous research indicated that how women were treated in hospital and whether they had been on the right medications before their stroke, could be responsible for their poorer outcomes.”
Dr Harris said that barriers and facilitators to women’s participation in stroke trials needed to be explored both at the trial and patient level to help redress the balance.
“Achieving a better gender representation in stroke trials can provide a more reliable assessment of the treatment benefits and harms, and inform treatment guideline recommendations for women affected by this serious condition,” she said.
While the United States, Canada and some European countries, adopted policies to boost the number of women in clinical trials over the course of the study, the results showed no change over this time.
“Our study suggests those efforts have clearly not translated into action,” Dr Harris added.
‘I’m determined this won’t be the final chapter in my life’
Survivor Adrian Day is looking to the future with hope after having a stroke and being made redundant within a week
Having had a stroke and lost his job within a week, Adrian Day is now committed to showing others there is hope even during the bleakest of times.
The 61-year-old had a stroke in May last year, during the height of the first wave of the COVID-19 pandemic, and only days later was told he would be made redundant.
But after a difficult year, Adrian is now looking to the future after making strong progress in his rehabilitation, and is determined to walk his daughter down the aisle on her wedding day in 2023.
“I’ve never felt depressed, or asked myself, ‘Why me?’ I actually consider myself lucky as haemorrhagic stroke kills more often than not but I’m still around to tell my story,” says Adrian.
“I’m also still here for my wife and daughters and I hope all of that brings inspiration and hope to other stroke survivors.”
It was while at home during COVID lockdown that Adrian began to realise something was not right, when he felt light-headed and could no longer feel his left arm or leg.
His wife noticed a slight droop in his face and called 999, explaining she suspected Adrian was having a stroke.
“The ambulance was on the drive in ten minutes. I was conscious and lucid throughout the stroke and I gave the paramedics as much information as possible on our way to hospital,” recalls Adrian, from Warrington.
A CT scan soon revealed Adrian’s stroke had been caused by a bleed on the brain and he would spend three days in Whiston hospital before being transferred to Warrington hospital.
But just one week after this, Adrian received devastating news about his job as an international development manager.
“On May, exactly one week after my stroke, and still paralysed, my boss emailed me to say that I would be redundant from May 31,” he says.
“The world was at the start of a global pandemic, the UK was in lockdown, I had suffered a stroke, I was paralysed and had just lost my job – I couldn’t believe what was happening.”
But despite two life-changing events in the space of a few days, Adrian has stayed determined in his recovery and getting his life back on track.
He began intensive sessions of physio and occupational therapy, while setting himself the goal of walking out of hospital by his 61st birthday.
Now back at home and continuing his rehabilitation, Adrian wants to show others that there is hope after stroke.
“Whilst I accept that I wont be the person I was before the stroke, I’m determined that it won’t be the final chapter in my life,” he says.
“I want to get another job, I’ve even had a few interviews and I want to drive again too.
“I knew life for me was going to be very different from now on. I was worrying about being unemployed and looking after my family.
Adrian and his family have been supported by The Stroke Association in being able to rebuild their lives.
“The Stroke Association spoke to my wife Carol, drafted a letter to my former employer and put me in touch with Citizens Advice,” says Adrian.
“They also offered me the opportunity to talk. They were sympathetic, they listened, offered advice and it helped, it really did.”
Laid bare: the reality for stroke survivors
Research highlights how survivors are impacted physically, mentally, emotionally and financially
The practical, emotional and physical impact of having a stroke and living with its consequences has been laid bare in new research.
Thirty per cent of survivors aged under 60 said having a stroke cost them their job, with six per cent of people saying their situation led to them losing their home.
Nearly a quarter – 23 per cent – said their stroke had a negative impact on their relationship with their partner, with almost one in ten of the 3,500 people surveyed saying stroke had led to the breakdown of their relationship.
Sixty per cent of stroke survivors aged under 50 say they have never emotionally recovered from their experience, which compares to 44 per cent for older people.
In terms of physical recovery, half of all survivors say they feel they continue to live with consequences.
The study, from the Stroke Association, gives insight into the huge challenges survivors face in all aspects of their lives.
It also found that hope is a crucial factor in recovery, with 76 per cent of people saying it played an important part in them being able to rebuild their lives.
While a quarter of survivors say they began to feel hope in the first month after their stroke, for 22 per cent, it took more than a year.
The importance of small and huge milestones in recovery was highlighted in the research, with 17 per cent of people saying their first moment of hope came when they were able to use their affected side for the first time, and 11 per cent said it was being able to speak again – whereas for 15 per cent of people, it was being able to complete a small everyday take like making a cup of tea.
But for 13 per cent of people, they admit to never feeling hopeful after their stroke, showing the sad reality that many survivors face.
The Stroke Association is a key supporter of stroke survivors, and helps them to rediscover the hope needed to rebuild their lives through specialist services including a helpline, peer support service, support groups and support coordinators.
Juliet Bouverie, chief executive of the Stroke Association, said: “Every five minutes, someone in the UK will have a stroke and in a flash, their life is changed.
“Two thirds of people who survive a stroke find themselves living with a disability. The physical impact of a stroke is severe, but for many, the emotional aspects of coming to terms with having a stroke are just as significant.
“As the research makes clear, finding hope is a crucial part of the recovery process. Without it, recovery can seem impossible.
“At the Stroke Association, we support and help people to find this hope, and rebuild their lives. But with 1.3million people and rising in the UK now living with the effects of a stroke, our services have never been more stretched. We urgently require the support of the public to help us continue to support stroke survivors to rebuild their lives.”
Inpatient rehab1 week ago
QEF appeal hits £1million milestone
Interviews4 weeks ago
Emilia Clarke’s SameYou – a catalyst for change
Insight1 week ago
How housing design can improve quality of life
News4 weeks ago
Robot with ‘potential to redefine neurorehab’ unveiled by Fourier
News4 weeks ago
Webinar to assess the Rehabilitation Prescription
News4 weeks ago
Sexual trauma ‘could lead to neurological conditions’
News4 weeks ago
Zen Koh takes on global change-maker role
Brain injury3 weeks ago
Blood test set to transform detection of brain damage after head injury