Back in 2000, the world was a very different place, particularly in terms of technology.
Many of the high-tech innovations we now accept as standard were not yet launched and healthcare remained one of the most traditional markets around.
Yet into this climate, Hocoma launched the prototype of its pioneering Lokomat, a robotic medical device which provides repetitive and highly physiological gait training to patients, enabling even some of the most impaired to learn to walk again.
While it has gone on to become one of the world’s leading robotic medical devices, in 2000, it was a significant and controversial disruption into a long- established and relatively low-tech rehab scene.
Clemens Muller, global head of clinical and scientific affairs at Hocoma, says: “Twenty years ago, gait rehabilitation was completely different.
Therapists had to physically move patients’ legs – a manual task that can be very tiring and requires huge effort, particularly when you are doing it many times a day.”
Gery Colombo, a trained electrical engineer with an interest in neural rehabilitation, founded Hocoma alongside Peter Hostettler, an economist, and Matthias Jörg, a biomedical engineer.
“The founders realised the need for a change to this way of doing things and to find a better solution,” says Clemens.
“They wanted to establish a venture which could use their specialist knowledge and go in a particular direction, with a purpose and intention.
“The goal was to change rehab as it was known. This was absolutely new; in fact so new and innovative that the world of healthcare rehabilitation wasn’t really ready for it.
“This was a challenging phase but one in which Hocoma needed to be really entrepreneurial with a very clear vision and focus and to keep on going.
“It did take a little while until it was accepted and it was a long journey for the founders.”
Despite the initial challenges of launching such a high- tech product, over the past two decades, the Lokomat has become one of the most widely used gait rehabilitation devices in the world.
It has helped to set an industry standard in rehab products for people with brain injury, stroke and other neurological disorders.
Hocoma recently installed its 1,000th Lokomat.
But it has also built on the success of its flagship product by launching an array of other devices.
Among its product portfolio is the Erigo, which assists with patient mobilisation in the earliest stages of rehabilitation; its Armeo range, which supports the recovery of arm and hand function; and its Valedo products that targets back pain.
The business is headquartered in Switzerland but works in 27 countries worldwide – and believes it is changing the lives of people in clinics across the globe.
Clemens says: “I think there are three drivers behind innovation in healthcare – social aspect, which includes demographic changes and the shift from using products which are based on evidence rather than just experience; the technology changes in the world as a whole; and the clinical changes, which are moving on quickly and have changed dramatically to encompass robotics and exploit the previously unused potential of this way of therapy.
“These drivers have changed, and continue to change, the landscape of the world in which we work. Hocoma has always been at the front pushing the boundaries and helping to change the resistance there was at the beginning of our journey.
“When you went to a rehab conference 15 or 20 years ago, there was only one tech provider there, which was us.
“But if you compare that to now, there can be anything up to 20 companies at an event, including start-ups that are working in technology fields like robotics or sensor-based equipment, offering products for inpatients and outpatients, for acute needs. So there is a huge selection now available.
“There is also the demand from the market to integrate technology. The key for us has always been how to integrate this technology into a routine of therapy to use it to its full potential.
“It is about not only being engineering-driven but understanding how to use that to make a bridge to the rehab world and understand the link to the human world – bringing the know-how and capability and opening that up for the needs of patients.
“As a market, we do need to do more homework in that area.
“Lots of clinics already have integrated the technology they are using very successfully, and with our products it makes us proud to see how the patient is being supported to the highest level.
“I have seen this happening in many clinics around the world and it gives me goosebumps to see how happy patients are with how it is working for them. It also makes a huge difference to the work and demands placed on the therapist, and that is something that also makes us so proud.”
Now celebrating its 20th anniversary, Hocoma’s ambition for the future is to continue changing lives and reaching out to millions more around the world.
A strategic move in achieving this came in 2017 when Hocoma joined its now-parent company DIH – bringing it under the same roof as other rehab technology developers including Motek.
“We have always been a pioneer since we were established so we will continue this with new and better solutions to benefit people’s lives.
“Our focus is on bringing solutions which are innovative, high quality, effective and efficient.
“The future for us will of course be affected by the healthcare market in general. We are seeing a rapid demographic change around the world and this will mean a change in the healthcare approach.
“There will be a search for solutions.
“With the huge move towards digitalisation through the Industrial Revolution 4.0, there will be a greater role played by artificial intelligence and virtual reality.
We will continue to develop as a business so we can continue to be at the front of what is happening.
“Traditionally, we have come up with a new innovation every year, which could be a new product launch, or else new features or a new version of an existing product, but we are always developing what we have to make it the best it can be.
“We are always learning by doing and have a network of research and academic partners all over the world and this enables us to come up with great products which deliver solutions.
“We are planning heavily in our development team and are continuing to develop our launch plan and product road map.
“We hope the global coronavirus outbreak and the shutdown we are seeing around the world does not affect our plans too much in the short-term, but we will have to see how that develops and adapt to that as we need to.”
As a business which has helped to change traditional practices and approaches in rehab globally, one area in which Hocoma would like to push for further change is in widening patient access to its own products, and other high-tech solutions.
“At the moment, it is not a given that all patients and all clinics will have access to our products. Of course technology has its price, but we need to address that at some point.
“We need to work with clinics and insurance companies to try and find a solution here and to shape the future of rehabilitation.
“It is important to find optimal solutions which increase access to technology, to improve the quality of rehab, while looking at the cost effectiveness of such products.
“Over the next five to 10 years, there are going to be more stroke, cerebral palsy and traumatic brain injury patients who are needing innovative solutions and our goal is to develop more solutions which will benefit them and the therapists.
“When money and costs are involved it can often be a long journey, but we believe if all stakeholders got together to find a way of best dealing with this, together we could deliver the best rehab to patients, and this is something we would like to be involved in delivering.”
More Delicious Innovations from Wiltshire Farm Foods
The latest Softer Foods creation from Wiltshire Farm Foods features an innovation which is entirely unique to the market: the shaping of a Level 5 Minced meal.
The company’s development team decided to incorporate this particular feature to enhance the visual element of its new Minced Cod in Parsley Sauce to further support those with swallowing difficulties in ensuring they receive the nutrition they need.
Committed to creating meals as delicious as they are visually appealing, Wiltshire Farm Foods understands how the aesthetic appeal of a plate of food can impact the appetite. Giving its customers the ability to eat independently with meals that look enticing ensures dignity in dining; something the company is passionate about.
Emily Stuart is the registered dietitian for the company and comments on importance of texture when it comes to those with swallowing difficulties:
“The texture of the main meal component has been designed in line with the requirements for an IDDSI Level 5 meal, in an extremely thick sauce. A Level 5 meal should require little to no chewing, ensuring a safe consistency for those on a Minced and Moist diet.
“All our Minced meals come ready-prepared, delivered directly to customers’ doors, to eliminate the risk that often accompanies home-blending. There are numerous challenges in creating safe, compliant meals via home blending with the process being both time consuming for carers and potentially hazardous for patients.”
Stroke survivor, Kate Allatt, knows first-hand how debilitating living with dysphagia can be, having experienced social isolation and embarrassment around mealtimes when friend and family were eating solid food that she was unable to consume herself:
To view the full Softer Foods range from Wiltshire Farm Foods along with more information on the latest Minced meals visit: specialistnutrition.com
Forget brain regions, it’s all about networks in neuroscience
Having worked for some of the biggest media outlets in the science industry, Dr Ginny Smith has been making brain science accessible for several years. With the release of her first solo book, she sits down with NR Times to discuss the ever-changing world of neuroscience.
The neurotransmitters in our brains and the chemicals that go with them continue to puzzle scientists and academics.
Making sense of it all is Dr Ginny Smith with the release of her new book.
Overloaded: How Every Aspect of Your Life is Influenced by Your Brain Chemicals explores how chemicals control what we do, from basic survival instincts to more complex processes, like forming relationships.
Recognised by New Scientist as one of the top science books in 2021, Overloaded was two years in the making.
One of its central themes is the brain working within networks which are all connected, rather than the traditional notion of individual regions performing specific tasks.
Speaking to NR Times, Dr Smith – who has produced science programmes for the BBC, Cosmic Shambles and the Naked Scientist – explained how changes in technology have brought about different interpretations of how the brain works.
“This idea of regions of the brain that do X or Y is starting to feel a bit outdated,” she said. “Talking to neuroscientists now, it’s all about networks and combinations of regions that talk to each other.”
And this shift in our understanding of the brain could shape new treatments in future.
“The drugs we have at the moment are the best thing that we have, but boosting things everywhere is a bit of a blunt instrument in something so precise as the brain.
“It’s not about if you need something to function, then having more of that is good. No, it’s all about finding that Goldilocks spot.
“One of the things I’m quite excited about for the future is the idea that we might be able to get more granular as to which areas of the brain are actually affected, perhaps on a person-by-person basis.
“It may be that at some point in the future, if you go to your doctor experiencing depression or anxiety, they could scan your brain to find out which area is actually affected and somehow target drugs specifically to that area.”
Overloaded brings together over 30 experts to give a clearer insight into how molecules like adrenaline, dopamine and serotonin work.
These chemicals may sound familiar but they often bring a lot of confusion around what they actually do – something Dr Smith was keen to address.
She explained how the misrepresentation of these substances in the media motivated her to set the record straight with the book.
“I started seeing a lot of mentions of these various brain chemicals. But they were often really oversimplified; like this idea that serotonin is the ‘happiness chemical’.
“It was stuff that takes a kernel of truth from real neuroscience, but simplifies it to the point where it no longer makes any sense at all.
“So I thought that it would be quite interesting to delve into a bit more complexity and find out what is actually going on and how much do we actually know about these chemicals?”
Although now hugely passionate about neuroscience, Dr Smith admitted that she fell into the subject after initially applying to study chemistry at the University of Cambridge.
“The way I’d encountered it before had been much more at the social psychology end of things, but the way it was taught here was like it was it was a real science where you did experiments.
“The complexity of the subject attracted me to it and I like a challenge. But also that the questions around it seemed so important to me. They seem like such vital questions to answer.”
Dr Smith switched her focus to neuropsychology and from here worked part-time in a lab. Due to her self-admitted short attention span, however, she found herself more drawn to the communication aspect of the field.
“I’ve been talking about the brain to anyone who will listen since then,” she said.
Her ability to make neurochemistry coherent was the catalyst for Braintastic! Science, the platform she founded to educate young people about how their brain works.
“Psychology and neuroscience aren’t sciences you necessarily meet at school. But one of the things I like is them explaining that there’s this whole other branch of science that they might not come across.
“It’s important to have a basic understanding of the brain. It can be so useful in so many ways.”
Indeed, a good understanding of the brain is something Dr Smith would liked to have had as a youngster.
“I wish that when I’d been a teenager, I had known a bit more about how a teenager’s brain works. I think it would have made life so much easier.
“Parents also understanding more about how young people’s brains develop would help them understand and relate to them.”
In fact, greater brain knowledge across the board in wider society would be beneficial, she believes.
“I think everyone can benefit from knowing a little bit more about how their brains and how other people’s brains work. I think it would make us a kinder, more tolerant society.”
While covering big neuroscience topics, the book is characterised by personal experiences and stories.
“One of the things I really like when I’m talking to scientists is hearing their passion and their stories for why they got into doing what they do.
“It also shows how science relates back to everyday life. That’s the thing about neuroscience and psychology, it’s all about us.
“I can’t tell you everything about the brain in one book, but I hope it sparks readers’ curiosity, and makes them want to go out and find out more about their brain.”
How the C-Brace is opening up a new world of possibilities
The C-Brace is big news in the progression of Orthotic treatment for neurological conditions. The integration of microprocessor technology into a carbon fibre Knee Ankle Foot Orthosis (KAFO’s) opens up a whole new world of possibilities and mobility for patients dependent on full leg support to stand and walk.
As standard, KAFO users are supplied with locked knee KAFOs. This is where the knee is locked in a straight position throughout their gait cycle, but manually unlocked to allow the user to sit down with their knee flexed. The use of a locked KAFO brings about stability of the knee for users with reduced lower leg muscles strength, when walking on level ground.
However, it also results in the development of multiple gait compensations for the user to progress through the gait cycle with a locked knee. Compensations include; hip hitching on the contralateral side, circumduction during swing phase, and vaulting of the contralateral ankle.
Gait can therefore be slower, require more metabolic energy and increase mechanical stress on the sound leg. Walking on slopes and stairs with a locked knee joint is very difficult and often situations avoided by KAFO users.
An alternative option to the locked KAFO is a Stance Control Orthosis (SCO). In a similar way to the locked KAFO, the knee joint is locked straight during stance phase, but unlocks at terminal stance to allow the knee to flex through swing phase, providing a more natural gait pattern and reduction in compensatory motions to achieve ground clearance.
SCOs require considerable confidence from the user, a consistent step length and are again limited on slopes, stairs and uneven ground. In order to prevent accidental disengagement of the knee lock on challenging surfaces, the user often manually locks the SCO.
Where the C-Brace comes into its own is the significant control available in both stance and swing phase of gait. The system provides stability for the foot and ankle, and stabilises the knee in the sagittal plane with the hydraulic unit replicating the eccentric and isometric muscle contraction of the quadriceps and hamstrings.
It controls both the stance and swing phases of gait with microprocessor sensor technology that can adapt to everyday situations in real time. The technology normalises gait by allowing controlled knee flexion during weight bearing, giving patients the ability to safely navigate quick stops, walk on uneven terrain, and descend slopes, curbs and stairs step over step.
The C-Brace calculates the orientation and movement of the system in space in three dimensions, using this information to control the flexion and extension valves of a hydraulic unit that provide varying levels of resistance to knee flexion. In turn, this allows for physiological knee flexion during loading response, absorbing the shock of weight transfer during heel strike.
In a locked KAFO or SCO, that shock is directly transferred to the pelvis and lumbar spine. Additionally, the C-Brace provides microprocessor swing control that adapts to the varying walking speeds of the patient. It does not require consistent step lengths to function as SCOs do.
Variable step length means a patient can increase or decrease walking speed and length of steps based on the instantaneous activity/mobility needs, making walking safer in unfamiliar or dangerous scenarios like crossing roads.
The C-Brace is also able to provide assistance descending stairs and slopes, allowing step-over-step gait, mimicking the contraction of the quadriceps for lowering the body down a stair or slope. The C-Brace considerably reduces stress to the sound limb in unilateral users, and allows bilateral users to descend stairs and slopes and ambulate on uneven terrain.
Additional features of the C-Brace include:
Stumble recovery: The microprocessor swing control of the C-Brace provides a stumble recovery feature that activates high knee flexion resistance during swing phase extension, in preparation for stance phase, allowing the patient to fully load their orthosis and stabilise the body in case of a stumble.
Intuitive Stance Function: This feature allows the patient to stand in a safe and relaxed manner with a flexed knee without the threat of knee collapse, and automatically switches back in to ambulation mode, turning off the blocked knee flexion when the patient moves. This feature allows the patient to unload the sound leg and rest while securely standing on level or non-level surfaces.
Sitting/Kneeling Function: The C-Brace assists the patient when sitting down and standing up from a chair by providing resistance to flexion or extension.
This adds an extra degree of safety and reduces stress to the upper extremities and the sound limb. The microprocessor automatically detects when the patient begins to sit down, adjusting the hydraulic resistance against bending during the transition to sitting.
Allowing the patient to sit in a controlled manner and at a controlled rate. When standing up from a seated position, the C-Brace blocks knee flexion as soon as the knee reaches a flexion angle of 45° or less, allowing the patient to reposition the foot and load the orthosis, for improved leverage to stand. The kneeling down function allows the patient to kneel down safely with controlled flexion of the knee joint, supported by increased flexion resistance.
Activity specific modes/Freeze mode: The C-Brace is programmable for activity specific needs of the patient in addition to ambulation. For instance, resistance can be reduced to a minimum for cycling, or a flexed knee joint position can be fixed for activities such as Yoga. The user, on their personal C-brace App, can control these modes.
So how can you know if the C-Brace might be right for your patient? The first stage is a thorough assessment, considering both the indications and contraindications of the system.
- Flaccid Paralysis or partial paresis of the lower limb
- Quadriceps deficiency leading to poor knee control during stance phase
The patient may present with regular ‘giving way’ of the knee, reporting stumbles or falls when walking on flat, graduated or uneven surfaces. The C-Brace may be appropriate for a number of neurological conditions, including but not limited to:
- Spinal cord injury between L1 and L5
- Multiple sclerosis
- Neuromuscular disease
- Muscular atrophy or Traumatic paresis
Essential requirements for the use of the C-Brace:
- The user must be able to stabilise their trunk and stand without support.
- The muscles strength of the hip extensors and flexors must allow the controlled swing of the affected leg, or this must be possible through compensatory hip/trunk movement.
Contraindications of the C-Brace:
- Swing phase initiation is not possible
- Insufficient trunk stability
- Severe spasticity
- Knee or hip flexion contracture of more than 10°
- Non correctable genu varus/valgus greater than 10°
- Body weight less than 40Kg or greater than 125Kg
- Height <140cm
- Leg length discrepancy >15cm
- Fluctuating Oedema or severe skin irritation that precludes the use of an orthosis
The C-Brace Dynamic Test Orthosis (DTO) is a trial orthosis, which features the C-Brace joint unit. The DTO can be set up to each individual user and programmed to their individual gait requirements, allowing users to test the function of the orthosis within the clinical setting.
The DTO can also provide valuable evidence to the function and benefits of the C-Brace for payers. The DTO can be trialled with support from the Ottobock Orthotic Academy Clinician or through Ottobock’s clinical partner Dorset Orthopaedic.
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